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7944184 
Journal Article 
ASYMMETRIC REDUCTIVE AMINATION OF CYCLOALKANONES .13. ENANTIOSELECTIVE AMIDOAMINATION - A NEW REGIOSPECIFIC STRATEGY FOR THE SYNTHESIS OF CHIRAL CYCLOHEXANE-1,2-DIAMINO-DERIVATIVES 
Schlichter, WH; Frahm, AW 
1993 
Yes 
Archiv der Pharmazie
ISSN: 0365-6233
EISSN: 1521-4184 
326 
7 
429-436 
English 
WOS:A1993LP44300010 
Asymmetric synthesis of trans‐ and cis‐2‐Benzamido‐ or 2‐Phenyl‐acet‐amido‐cyclohexane‐amines 7 and 8 by means of reductive amination and hydrogenolysis is described. Condensation of the amido‐ketones 3 with chiral auxiliary (R)‐(+) and (S)‐(‐)‐1‐phenylethylamine, respectively, leads to the amido‐imines 4, which are hydrogenated over Raney‐Ni to yield simultaneously enantiomerically pure secondary trans‐ and cis‐2‐amidocyclohexane‐amines 5 and 6. Copyright 1993 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim