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Citation
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HERO ID
7949654
Reference Type
Journal Article
Title
α-Terpineol reduces cancer pain via modulation of oxidative stress and inhibition of iNOS
Author(s)
Gouveia, DN; Costa, JS; Oliveira, MA; Rabelo, TK; Silva, A; Carvalho, AA; Miguel-Dos-Santos, R; Lauton-Santos, S; Scotti, L; Scotti, MT; Santos, M; Quintans-Júnior, LJ; Albuquerque Junior, RLC; Guimarães, AG
Year
2018
Is Peer Reviewed?
Yes
Journal
Biomedicine & Pharmacotherapy
ISSN:
0753-3322
EISSN:
1950-6007
Volume
105
Page Numbers
652-661
Language
English
PMID
29902764
DOI
10.1016/j.biopha.2018.06.027
Web of Science Id
WOS:000438312600074
Abstract
α-Terpineol (TP) is present in a wide range of essential oils of the genus Eucalyptus, with recognized potential for a range of biological effects, such as analgesic. Hence, our study aimed to investigate the effect of TP on cancer pain induced by sarcoma 180 in Swiss mice. Our results showed that TP reduced significantly mechanical hyperalgesia and spontaneous and palpation-induced nociception, improved paw use without reducing tumor growth and grip strength. Importantly, no evident biochemical and hematological toxicity was oberved. Furthermore, TP increased the tissue antioxidant capacity due to ferric-reducing antioxidant power (FRAP) and glutathione (GSH). TP also reduced inducible nitric oxide synthase (iNOS) immunocontent in the tumors. Molecular docking estimated that TP binds within the same range of iNOS regions (other iNOS inhibitors), such as N-Nitroarginine methyl ester (L-NAME). These data provide strong evidence that TP may be an interesting candidate for the development of new safe analgesic drugs that are effective for cancer pain control.
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