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HERO ID
7950069
Reference Type
Journal Article
Title
The conversion of fibrinogen to fibrin. VI. Flow birefringence studies on clotting systems inhibited by hexamethylene glycol
Author(s)
Foster, JF; Samsa, EG; Shulman, S; Ferry, JD
Year
1951
Is Peer Reviewed?
Yes
Journal
Archives of Biochemistry and Biophysics
ISSN:
0003-9861
EISSN:
1096-0384
Volume
34
Issue
2
Page Numbers
417-423
Language
English
PMID
14904077
DOI
10.1016/0003-9861(51)90020-3
Abstract
1. 1. Flow birefringence measurements have been made on inhibited clotting systems prepared by allowing bovine fibrinogen and thrombin to react in the presence of 0.5 M hexamethylene glycol and diluting the stock solution, which contains an intermediate polymer previously identified, to give various dilutions in 20 and 40% glycerol at constant glycol, salt, and buffer. 2. 2. The dependence of extinction angle on velocity gradient shows the presence of elongated particles of different lengths in the neighborhood of 4000 A., and the moderate dependence of extinction angle on concentration indicates that these particles do not disaggregate when solutions containing glycerol are diluted. 3. 3. The dependence of phase difference on concentration and velocity gradient also indicates that the particles do not change in length with dilution, at least down to a protein concentration of 1 g./l. 1951.
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