(+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7951476

Reference Type

Journal Article

Title

(+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids

Author(s)

Villegas, LF; Marçalo, A; Martin, J; Fernández, ID; Maldonado, H; Vaisberg, AJ; Hammond, GB

Year

2001

Is Peer Reviewed?

Yes

Journal

Journal of Natural Products
ISSN: 0163-3864
EISSN: 1520-6025

Volume

Issue

Page Numbers

1357-1359

Language

English

PMID

11678668

DOI

10.1021/np0102859

Abstract

Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-alpha-bisabolol (1) (ED(50) 155 microg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, alpha-bisabolol (2) and alpha-terpineol (3) (ED(50) of 228 and 240 microg/g mouse[corrected], respectively).