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7952352 
Journal Article 
Total synthesis of (+)-trans- dihydronarciclasine from (+)-7-azabicyclo[2.2.1]heptanone 
Smi, N; Ainali, NM; Agapiou, E; Papadopoulos, L; Papageorgiou, GZ; Bikiaris, DN; Pandey, G; Fernandes, R; Dey, D; Majumder, B 
2018 
1 
Tetrahedron
ISSN: 0040-4020 
74 
39 
5752-5757 
English 
WOS:000444664000020 
A concise asymmetric total synthesis of Amaryllidaceae alkaloid (+)-trans-dihydronarciclasine is accomplished starting from optically pure 7-azabicyclo[2.2.1]heptanone scaffold in 13 linear steps. Key features of the strategy include substrate-directed stereoselective installation of the trans B-C ring junction and regioselective Wacker-type internal olefin oxidation to provide a rapid access to all hydroxyl functionalities over the key cyclohexane ring in a stereocontrolled manner. 2018 Elsevier Ltd 
Amaryllidaceae alkaloids; (+)-trans-dihydronarciclasine; 7-Deoxy-pancrastatin; Trans-B-C ring junction stereochemistry; Wacker-type internal olefin oxidation