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8022262 
Journal Article 
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice 
Roberts, MN; Wallace, MA; Tomilov, AA; Zhou, Z; Marcotte, GR; Tran, D; Perez, G; Gutierrez-Casado, E; Koike, S; Knotts, TA; Imai, DM; Griffey, SM; Kim, K; Hagopian, K; Mcmackin, MZ; Haj, FG; Baar, K; Cortopassi, GA; Ramsey, JJ; Lopez-Dominguez, JA 
2017 
Yes 
Cell Metabolism
ISSN: 1550-4131 
26 
3 
539-546.e5 
English 
28877457 
WOS:000409244000009 
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.