Reactive oxygen species: stuck in the middle of neurodegeneration | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8024463

Reference Type

Journal Article

Subtype

Review

Title

Reactive oxygen species: stuck in the middle of neurodegeneration

Author(s)

Patten, DA; Germain, M; Kelly, MA; Slack, RS

Year

2010

Is Peer Reviewed?

Yes

Journal

Journal of Alzheimer's Disease
ISSN: 1387-2877
EISSN: 1875-8908

Volume

20 Suppl 2

Page Numbers

S357-S367

Language

English

PMID

20421690

DOI

10.3233/JAD-2010-100498

Web of Science Id

WOS:000280479600009

Abstract

Neuronal cell loss associated with neurodegeneration has recently been linked to mitochondrial dysfunction. Electron transport chain defects and reactive oxygen species (ROS) production are emerging as important players in the etiology of neurodegenerative diseases. Proper management of ROS and disposal of damaged cellular components are vital to the survival and function of neurons. Proteins involved in these pathways are often mutated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. In this review, we will discuss the roles of ROS in normal physiology, how changes in ROS production affect neuronal survival in neurodegenerative diseases, and the recent advances in mitochondrial antioxidants as potential therapeutics.