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8091205 
Journal Article 
EFFECTS OF THERAPY BY PHOSPHATE ON PARATHYROID-GLAND RESPONSE 
Guillemant, J; Dechasteigner, C; Guillemant, S 
1991 
1 
Therapie
ISSN: 0040-5957 
46 
6 
487-490 
French 
1819155 
WOS:A1991HF62700011 
The effects of a single oral dose of phosphate (780 mg of elemental phosphorus as 100 drops of Phosphoneurol 120 from DOMS-Adrian Laboratories) on parathyroid function and on calcium and phosphate metabolism were studied in 10 young adults. The parathyroid response was checked by measurement of PTH 1-84 and of nephrogenous cAMP before and after a 10 days therapy by phosphate (780 mg of elemental phosphorus twice daily). Before treatment a 16 per cent increase in PTH 1-84 (p less than 0.05) and a 34 per cent increase in nephrogenous cAMP (p less than 0.02) was obtained. After treatment the increases were respectively 34 per cent for PTH 1-84 (p less than 0.001) and 67 per cent for nephrogenous cAMP (p less than 0.001). The responses in PTH 1-84 and in nephrogenous cAMP were significantly (p less than 0.05 and p less than 0.01) higher after than before treatment by phosphate. 
PHOSPHATE; PARATHYROID HORMONE