Health & Environmental Research Online (HERO)


Print Feedback Export to File
8093711 
Journal Article 
Synthesis, characterization, antimicrobial and in-silico studies of (1,1-dibenzofuran-2-yl) ethyl terephthalamide derivatives 
Gurunathan, K; Desai Nivedita, R; Naika Hanuma, NR; Doyijode, AKB; Sreenivasa, S 
2021 
1 
Research Journal of Chemistry and Environment
ISSN: 0972-0626 
25 
5 
68-79 
English 
In search of new benzofuran derivatives of biological importance, symmetric terephthalamide derivatives of benzofuran (4a-e) were synthesized from 2-acetylbenzofuran. The synthesis of title compounds follows a sequence of condensation, reduction and coupling reactions. The structures of all the newly synthesized compounds are established by FT-IR, 1H and 13C NMR and MS spectral methods. The formation of amine follows novel reduction method under microwave irradiation. All the synthesized compounds were subjected to invitro antimicrobial studies and found to be moderate antibacterial agent and poor antifungal agents. In correlation, the mode of action of these compounds as antimicrobial agents was determined by the in-silico studies. © 2021 World Research Association. All rights reserved. 
2-acetylbenzofuran; Antimicrobial; Microwave irradiation; Molecular docking; Symmetric; Terephthalamide