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8095396 
Journal Article 
Development and in-vitro evaluation of taste masked ondansetron HCl oral dispersible tablets by direct compression method by using different diluents 
Vamshidhar Reddy, D; Doddayya, H; Saisirisha, A; Bharathi, T 
2012 
1 
International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 
4 
SUPPL.1 
254-260 
English 
Ondansetron hydrochloride is a competitive serotonin type 3 receptor (5-HT3) antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties with chemical name of 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one. It is an intensely bitter in taste. Bitter taste of the ondansetron is a major problem in ensuring patient compliance. The purpose of this research was to mask the intensely bitter taste of ondansetron HCl and to formulate an Oral dispersible tablet (ODT). In the present study an attempt has been made to mask the bitter taste, by complexation technique using ion-exchange resin, tulsion-335 (polyacrylic hydrogen with carboxylic functionality) and to formulate into an oral dispersible dosage form. Taste masking was done by complexation of ondansetron HCl with different ratios Tulsion 335 resin. The drug loading onto ion-exchange resin was optimized for concentration of resin ratio, swelling time of resin, stirring time and pH of resin solution. Resinate was characterized by DSC. Drug resin complexes were tested for drug content, Taste and in vitro release in simulated salivary fluid (SSF) of pH 6.8. Resinate that did not release drug in SSF was considered taste-masked and selected for formulation of oral dispersible tablets. The complex with drug-resin ratio 1:3 showed less amount of drug release in SSF; therefore, it was selected. The tablets were prepared with indion-414 as superdisintegrant. The blend was examined for angle of repose, bulk density, tapped density and hausner's ratio. The tablets were evaluated for hardness, drug content, friability, disintegration time and in vitro drug release study. The tablets disintegrated in vitro within 16 seconds and complex drug was released from tablet with in 2 min. The results concluded that ondansetron HCl was successfully taste masked and formulated into oral dispersible tablet. 
Ondansetron HCl; Oral dispersible tablets; Taste masking; Tulsion-335