Health & Environmental Research Online (HERO)


Print Feedback Export to File
8098494 
Journal Article 
Studies on medicinal resouces of rutaceous plants and development to pharmaceutical chemistry 
Ito, C 
2000 
Yes 
Journal of Natural Medicines
ISSN: 1340-3443
EISSN: 1861-0293 
54 
3 
117-122 
Japanese 
In a series of studies on bioactive constituents in medicinal plants of the family Rutaceae, a number of new coumarins, acridone alkaloids, and carbazole alkaloids were isolated, and their structures were elucidated by the chemical and spectroscopic methods. Some of the compounds demonstrated significant inhibitory effects on Epstein-Barr virus activation, suppressive effects on nitric oxide generation, and antiproliferative effects. Moreover, the substituted 7H- pyrido[4,3-c]carbazoles were synthesized from the natural product, murrayanine, which was isolated from Murraya species. The self-association of them and intermolecular interaction between 7H-pyrido[4,3-c]carbazole and adenine were studied. 
Acridone; Anti-HIV; Antiproliferative effect; Cancer chemopreventive agent; Carbazole; Coumarin; DNA intercalator; Epstein-Barr virus activation; Intermolecular interaction; Nitric oxide; Pyridocarbazole; Rutaceae; Self-association