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8099211 
Journal Article 
Carvedilol: Therapeutic application and practice guidelines 
Bleske, BE; Gilbert, EM; Munger, MA 
1998 
1 
Pharmacotherapy
ISSN: 0277-0008
EISSN: 1875-9114 
18 
4 
729-737 
English 
Current knowledge of the mechanisms contributing to progression of heart failure suggests that therapies that limit or interfere with the consequences of neurohormonal activation and improve myocardial energetics appear to be most beneficial. Carvedilol, a nonselective β-adrenergic blocker with peripheral vasodilating properties, reduces mortality, slows progression of disease, and improves quality of life in patients with heart failure when added to standard therapy. When administered according to recommended guidelines, carvedilol is well tolerated. Clinical guidelines on the use of carvedilol in heart failure are provided.