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8102108 
Journal Article 
Alterations in brain phosphorus metabolite concentrations associated with areas of high signal intensity in white matter at MR imaging 
Sappey-Marinier, D; Deicken, RF; Fein, G; Calabrese, G; Hubesch, B; Van Dyke, C; Dillon, WP; Davenport, L; Meyerhoff, DJ; Weiner, MW 
1992 
1 
Radiology
ISSN: 0033-8419
EISSN: 1527-1315 
183 
1 
247-256 
English 
1549681 
WOS:A1992HJ87400045 
Areas of high signal intensity in white matter are identified on brain magnetic resonance (MR) imaging studies in 25%-50% of elderly subjects. The authors used phosphorus-31 MR spectroscopy to characterize the metabolic status of hemispheric white matter brain volumes in 30 elderly subjects with white matter areas of high signal intensity at MR imaging. Compared with white matter volumes with no or minimal areas of high intensity, white matter volumes with extensive areas of high intensity evidenced a 26% decrease in the adenosine triphosphate (ATP)/inorganic phosphate (Pi) ratio (P = .03) and a 21% decrease in the ATP concentration (P = .05), with the Pi level unchanged. A pilot P-31 spectroscopic imaging study in a subject with a large, coalescing white matter area of high signal intensity demonstrated large reductions in metabolite concentrations in the high-signal-intensity area. These results suggest that extensive white matter areas of high signal intensity indicate a process that affects white matter cellular energy metabolism. 
Aging, 10.83; Brain, MR, 10.1214; Brain, white matter, 10.83; Dementia, 10.83; Magnetic resonance (MR), phosphorus studies, 10.1214; Magnetic resonance (MR), spectroscopy, 10.1214