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8104932 
Journal Article 
The synthesis of N-arylcyclopropylamines via palladium-catalyzed C-N bond formation 
Cui, W; Loeppky, RN 
2001 
1 
Tetrahedron
ISSN: 0040-4020 
57 
15 
2953-2956 
English 
A variety of N-arylcyclopropylamines has been prepared in one step, by the Pd2(dba)3/BINAP/NaOtBu-catalyzed amination of an aryl bromide with cyclopropylamine. Compounds bearing the N-aryl substitutent (phenyl, 4-methylphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-chlorophenyl, 1-napthyl, 9-anthryl, 9-phenanthryl, and 3-pyridyl) were prepared in isolated yields ranging from 43 to 99%. Overall, this chemistry represents a vast improvement over the previous multi-step procedures for the synthesis of compounds of this type. © 2001 Elsevier Science Ltd. 
Cyclopropylamine; N-arylation; N-arylcyclopropylamine; Pd catalysis