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8111117 
Journal Article 
Studies on the Metabolic Products Obtained from Mouse Skin after Painting with 3,4-Benzpyrene 
Stanley Tarbell, D; George Brooker, E; Seifert, P; Vanterpool, A; Claus, CJ; Conway, W 
1956 
Yes 
Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445 
16 
1 
37-47 
English 
1. Observations (19, 28, 38, 39, 45) that fluorescent material is chemically bound to skin protein of benzpyrene-painted mice are confirmed. 2. The existence of an acidic metabolite, as reported by Miller, was confirmed. No neutral substance possessing a fluorescence spectrum different from the controls was found. 3. The acidic “metabolite” has fluorescence bands at 4390-4400 and 4670-90 A which are altered on acetylation and restored on deacetylation. 4. On the basis of fluorescence spectra and chemical behavior it appears that the acidic “metabolite” is different from metabolites (3, 38, 39) reported previously. 5. 5,8-Dimethoxy-3,4-benzpyrene shows the same fluorescence spectrum but is not identical with the “metabolite.” 6. The ultraviolet absorption and fluorescence spectra of several model compounds are tabulated. © 1956, American Association for Cancer Research. All rights reserved.