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8114089 
Journal Article 
Antioxidant activity of mangosteen peel (Garcinia mangostana L.) extracted using different solvents at the different times 
Kusmayadi, A; Adriani, L; Abun, A; Muchtaridi, M; Tanuwiria, UH 
2019 
JPR Solutions 
11 
1 
44-48 
English 
Background: Extraction is conducted to extract the important compounds in mangosteen peel using solvents at the different time. Extraction time needs to be calculated so that the bioactive compound can be extracted optimally using the most efficient solvent. The extraction of mangosteen peel was conducted by soaking in solvent at particular time (1-2 days in general) without heating. Aim: This study aims to evaluate the effect of different solvents and maceration time on antioxidant activity of mangosteen peel extract. Materials and Methods: The present research was conducted by extracting mangosteen peel using ethanol (EtOH), acetone (Ace), ethyl acetate (EtOAc), methanol (MetOH), hexane (HX), acetic acid (AcetAc) and aquadest (Aqua) at 24, 36 and 48h. Antioxidant activity was examined using visible UV spectrophotometer at the particular wavelength. Result and Discussion: The result showed that the type of solvent and extraction time significantly (P<0.01) affected antioxidant activity. Acetone extract of mangosteen peel is the most optimal solvent for antioxidant activity in extraction time for 24 hours (IC 50 = 9,468 + 0,324 ppm). A further test was required to obtain a better result using HPLC method. Conclusion: It was evidenced that the properties of solvents, particularly polarity index and time, significantly affected antioxidant activity. © 2019 American Association for the Advancement of Science.All right reserved. 
Antioxidant activity; Maceration time; Mangosteen peel extract; Solvents