US EPA

8115165 

Journal Article 

Anti-alopecia activity of waste cacao (Theobroma cacao L.) peels 

Mustarichie, R; Hasanah, AN 

2019 

JPR Solutions 

11 

9 

2194-2199 

English 

Objective: Hair loss (alopecia) is the most common hair problem. The objective of this study was to determine the activity of growth stimulant activity of cacao (Theobroma cacao L.) fruit peels. Materials and Methods: The cacao peel extract was extracted with ethanol 96% solvent and fractionated with water. n-hexane and ethyl acetate solvents and then tested for hair growth stimulant activity of extracts and waste cacao peels fraction with modified Tanaka et al. method. In this test, the concentration of ethanol extract of cacao fruit peel was diluted to 5%, 10%, 15%, 20%, and 25% which were tested in test animals, namely, rabbits. Results and Discussion: The results showed that the test results showed that the ethanol extract of cacao fruit peel effluent had a hair growth stimulating activity starting at a concentration of 15%. In testing the fraction of cacao fruit peel fraction, it was found that the n-hexane fraction had the best activity compared to the other fractions and positive controls (minoxidil 2%). All data obtained in the study were analyzed statistically. Conclusion: Waste cacao peels ethanol extract had a growth stimulant activity at a concentration above 15% with the n-hexane fraction had the best activity. © 2019 JPR Solutions. All rights reserved. 

Anti-alopecia; Cacao fruit peel waste; Extraction; Hair loss; Theobroma cacao