Health & Environmental Research Online (HERO)


Print Feedback Export to File
8115523 
Journal Article 
Inhibitory activity of compound isolated from n-hexane fraction of bay leaves (Syzygium polyanthum (Wight) Walp) against xanthine oxidase 
Sumiwi, SA; Zuhrotun, A; Rusdiana, T; Khoirunnisa, R 
2019 
1 
Research Journal of Chemistry and Environment
ISSN: 0972-0626 
World Research Association 
23 
7 
25-28 
English 
Hyperuricemia is a metabolic disease associated with high purines diet and alcoholic beverages that cause high levels of uric acid. The formation of uric acid can be inhibited by xanthine oxidase (XO) inhibitor. The bay leaves contain flavonoid compounds, polyphenols, alkaloids, tannins and essential oils. Based on previous research, the bay leaves n-hexane fraction has inhibitory activity of XO in vitro. This research was conducted to isolate the active compounds in the nhexane fraction of bay leaf and to know the inhibitory activity of the isolated compounds on XO. Tests were performed in vitro by using UV-Vis spectrophotometry in various concentration variations. The results showed that compound A and compound B actively inhibit XO activity with 50 value of 4.29 μg/mL and 2.98 μg/mL respectively. Allopurinol, the drug standard's 50 was 0.42 μg/mL. © 2019 World Research Association. All rights reserved. 
In vitro; Indonesian bay leaf; Inhibitory activity; Xanthine oxidase