Health & Environmental Research Online (HERO)


Print Feedback Export to File
8138710 
Journal Article 
Review 
Mechanisms of bile formation, hepatic uptake, and biliary excretion 
Klaassen, CD; Watkins, JB 
1984 
1 
Pharmacological Reviews
ISSN: 0031-6997
EISSN: 1521-0081 
36 
1 
1-67 
English 
6144113 
Biliary excretion of xenobiotics is a complex process involving uptake into liver cells, intracellular sequestration and/or biotransformation, and transport into bile. A description of liver morphology and the possible mechanisms of bile formation is included to aid in the understanding of how chemical and physiological factors affect bile flow, hepatic uptake, and biliary excretion. Enterohepatic circulation interferes with the biliary elimination of xenobiotics from the body. The considerable volume of information that has accumulated in recent years on the mechanisms of bile formation, hepatic uptake, and biliary excretion is discussed in this comprehensive review. 
Animals; Bile/metabolism/physiology; Bile Acids and Salts/metabolism; Bile Ducts/physiology; Chemical Phenomena; Chemistry; Chemistry, Physical; Cholagogues and Choleretics/pharmacology; Cholelithiasis/metabolism; Cholestasis/metabolism; Enterohepatic Circulation; Liver/metabolism; Membranes/metabolism; Microsomes, Liver/metabolism; Neurotransmitter Agents/physiology; Pharmaceutical Preparations/metabolism; Proteins/metabolism