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HERO ID
8141089
Reference Type
Journal Article
Subtype
Review
Title
The Role of Th17 Response in COVID-19
Author(s)
Martonik, D; Parfieniuk-Kowerda, A; Rogalska, M; Flisiak, R; ,
Year
2021
Publisher
MDPI
Location
BASEL
Page Numbers
1550
Language
English
PMID
34205262
DOI
10.3390/cells10061550
Web of Science Id
WOS:000665585500001
URL
https://www.mdpi.com/2073-4409/10/6/1550
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Abstract
COVID-19 is an acute infectious disease of the respiratory system caused by infection with the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission of SARS-CoV-2 infections occurs through droplets and contaminated objects. A rapid and well-coordinated immune system response is the first line of defense in a viral infection. However, a disturbed and over-activated immune response may be counterproductive, causing damage to the body. Severely ill patients hospitalised with COVID-19 exhibit increased levels of many cytokines, including Interleukin (IL)-1β, IL-2, IL-6, IL-7, IL-8, IL-10, IL-17, granulocyte colony stimulating factor (G-CSF), monocyte chemoattractant protein 1 (MCP-1) and tumor necrosis factor (TNF). Increasing evidence suggests that Th17 cells play an important role in the pathogenesis of COVID-19, not only by activating cytokine cascade but also by inducing Th2 responses, inhibiting Th1 differentiation and suppressing Treg cells. This review focuses on a Th17 pathway in the course of the immune response in COVID-19, and explores plausible targets for therapeutic intervention.
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