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5930592 
Journal Article 
Effect of quercetin on selected micro elements in rat liver tissue during carbon tetrachloride exposure 
Akkoyun, HT; Akkoyun, MB 
2019 
1 
Fresenius Environmental Bulletin
ISSN: 1018-4619
EISSN: 1610-2304 
28 
9 
6757-6763 
English 
WOS:000485852800047 
The aim of this study was to investigate the effects of carbon tetrachloride and quercetin on selected trace element levels such as Cr (Chromium), Mn (Manganese), Fe (Iron), Cu (Copper) in rats. In the study, 28 male Wistar albino rats (200 +/- 300 g) were used. Rats were divided into 4 groups as Control, CCl4 (carbon tetrachloride), Qu (quercetin), Qu + CCl4 (quercetin + carbon tetrachloride) (n=7 in each group). When Cr (mu g/g) amount was examined an increase was observed in Qu administered group (p <0.01) compared to the control. It was increased in Qu (p <0,05) and CCl4 + Qu (p <0,001) treated groups compared to CCl4 group. Mn decreased in CCl4 and CCl4 + Qu groups compared to control. Fe (mu g/g) content was increased in CCl4, CCl4 + Qu and Qu (p<0.01) groups compared to Control. An increase in Qu treated group compared to CCl4 applied group (p<0.05) was observed. The CCl4 + Qu group decreased compared to the Qu group (p<0.01). Cu content of CCl4 and Qu groups showed an increase whereas CCl4 + Qu applied showed a decrease compared to control. As a result; It is thought that quercetin may have an effect on important trace element levels such as Cr (Chromium) Mn (Manganese), Fe (Iron), Cu (Copper) in the case of oxidative stress caused by carbon tetrachloride. 
CCl4; Quercetin; Trace element; Liver