P(III)-ACRIDINE DERIVATIVES AS BUILDING-BLOCKS FOR THE SOLID-PHASE SYNTHESIS OF NON-RADIOACTIVELY LABELED OLIGONUCLEOTIDES | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8156652

Reference Type

Journal Article

Title

P(III)-ACRIDINE DERIVATIVES AS BUILDING-BLOCKS FOR THE SOLID-PHASE SYNTHESIS OF NON-RADIOACTIVELY LABELED OLIGONUCLEOTIDES

Author(s)

Moller, U; Cech, D; Schubert, F

Year

1990

Is Peer Reviewed?

Journal

Liebigs Annalen der Chemie
ISSN: 0170-2041

Publisher

VCH PUBLISHERS INC

Location

DEERFIELD BEACH

Issue

Page Numbers

1221-1225

Web of Science Id

WOS:A1990EU93800008

Abstract

In contrast to 9-(2-hydroxyethyl)-10-methylacridinium salts 5 9-(2-hydroxyethyl)acridine (2) proved to be a useful intermediate for the synthesis of 2-(9-acridinyl)ethyl phosphoramidites 8 or 2-(9-acridinyl)ethyl H-phosphonates 9 suitable for the introduction of acridine into oligonucleotides. The phosphorous compounds 8 and 9 were synthesized by modified standard procedures. The phosphoramidites and H-phosphonates of 2 are attached to the 5' end of different oligonucleotides in the last cycle of the solid-phase synthesis.

Keywords

ACRIDINE LABELING; PHOSPHORAMIDITES; H-PHOSPHONATES; OLIGONUCLEOTIDE SYNTHESIS