US EPA

8156776 

Journal Article 

Thermogravimetric and antimicrobial properties of some divalent metal complexes of hexamethylenetetramine 

Agwara, MO; Foba-Tendo, JN; Amah, C; Yufanyi, DM; Ndosiri, NB 

2012 

0 

Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 

3 

3 

95-104 

English 

Mn(II), Co(II), Ni(II), and Zn(II) sulphate complexes with HMTA have been synthesised and characterised by elemental analyses, melting points, IR and UV-visible spectroscopy, magnetic susceptibility and thermogravimetric analyses. The results suggest an octahedral coordination environment in which the central metal ion is covalently bonded to six aqua molecules. HMTA is bonded to the water molecules through hydrogen bonding. The complexes decompose on heating to form oxide residues. The ligand, HMTA and its metal complexes were screened in vitro for antibacterial activity against nine pathogenic bacteria strains. The activity data indicate that the metal complexes are more potent antibacterial agents than HMTA against the nine bacteria strains. 

Antimicrobial; Biological; Hexamethylenetetramine; Metal(II); Thermogravimetric