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8159159 
Journal Article 
Synthesis, characterization and biological activity of new metal complexes of N-(4-(2-hydrazinyl-2-oxoethoxy)phenyl)acetamide 
Abdel-Monem, YK; Amer, HH; Mandour, HS; Alkafaween, IK 
2016 
0 
Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 
7 
3 
1682-1697 
English 
Seven metal complexes derived from N-(4-(2-hydrazinyl-2-oxoethoxy)phenyl)-acetamide (hydrazide of paracetamol) were prepared and characterized. Different standardized instruments were used for obtaining the required data (spectral method UV-vis., IR, 1H-NMR, mass spectra) magnetic susceptibility and thermogravimetric analysis TGA were performed. The electronic spectral data and magnetic moment values proved that all the metal complexes except copper (II) and vanadium (IV) complex have octahedral geometry, whereas copper complex has square planar structure and vanadium complex has square pyramidal. Antibacterial screening of the ligand and its complexes against Escherichia coli (E.coli) and Staphylococcus aureus (S. aureus), was also investigated. The ligand and its metal complexes were found to have varied degree of inhibitory effect against the bacteria. The results obtained proving the potentials of these compounds as broad-spectrum antimicrobial agents. © 2010 RJPBCS. 
Antimicrobial activities; Chelate complex; Paracetamol hydrazide