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8171810 
Journal Article 
Isolation and identification of quercetin derivatives and their α-glucosidase inhibitory acitivities from bryophyllum pinnatum 
Sofa, F; Akhmad, D; Megawati, M; Muhammad, H 
2018 
1 
Research Journal of Chemistry and Environment
ISSN: 0972-0626 
World Research Association 
22 
Special issue II 
114-119 
English 
In our ongoing investigation on chemical constituents from Indonesian medicinal plants, we have isolated and evaluated antidiabetic effects on α-glucosidase of quercetin derivatives from Bryophyllum pinnatum leaves. The methanolic extract was first separated into n-hexane, ethyl acetate and water-soluble fractions. The ethyl acetate fraction was further purified with silica gel column chromatography techniques based on bioassay guided fractionation which led to 3',4'- dimethoxy quercetin and two flavonoid glycosides, quercetin 3-O-α-L-rhamnoside (1) and quercetin-3-O- α-L-arabinopyranosyl (1→2)α-L-rhamnopyranoside (2). The chemical structures were determined by extensive spectroscopic analyses, namely, UV/Vis, FTIR, LCMS, 1D and 2D NMR. All isolated compounds have a;- glucosidase inhibitory activity with IC50103.20, 83.83 and 110.52 μg/mL respectively. © 2018 World Research Association. All rights reserved. 
Bryophyllum pinnatum; quercetin derivatives; α-glucosidase inhibitors