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8173122 
Journal Article 
Trace elements and postmenopausal osteoporosis: A preliminary study of decreased serum manganese 
Reginster, JY; Strause, LG; Saltman, P; Franchimont, P 
1988 
1 
Medical Science Research
ISSN: 0269-8951 
16 
7 
337-338 
English 
10 postmenospausal (PM) osteoporotic (PMO) women have been compared to 20 age-matched PM healthy women. We find a highly significant difference between groups in the parameters reflecting bone mass, trabecular bone volume obtained from bone biopsies (p < 0.001) or bone mineral content or bone mineral density measured by dual photon absorptiometry of lumbar spine (p < 0.001). Bone calcium was also significantly lower in the osteoporotic group (p < 0.01). No difference has been recorded between groups in histological parameters reflecting bone formation (osteoid volume, osteoid surfaces) or bone resorption (osteoclastic resorption surfaces) neither in serum bone gla-proteins, a biological reflect of bone formation. Bone trace elements (Copper, Manganese, Zinc) were not statistically different in PMO and controls. Serum determination of trace elements showed a significant decrease of serum manganese in the PMO group (p < 0.05) whereas serum copper and zinc were similar. This difference in serum manganese might be a useful test to determine high risk patients for developing postmenopausal osteoporosis.