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8176042 
Journal Article 
Enhancement of sodium excretion by intake of psyllium husk -A randomized, double-blind, placebo-controlled, crossover trial 
Yoshinuma, H; Inoike, N; Tanabe, S; Tanaka, M; Takara, T; Nakamura, F 
2019 
0 
Yakuri to Chiryo / Japanese Pharmacology and Therapeutics
ISSN: 0386-3603 
47 
9 
1509-1518 
English 
Objectives The aim of this study was to investigate whether the intake of dietary fiber derived from psyllium husk reduces the amount of sodium absorbed into the body in healthy Japanese men. Methods We conducted a randomized, double-blind, placebo-controlled, crossover trial in healthy Japanese adult males (mean age 43.3±9.2, n = 2 l) . Subjects consumed the provided meals for the first two days of each study period and the test capsules at breakfast on Day 2. The test capsules contained psyllium husk (4 or 10 g) or placebo (dextrin). Stools were collected the day after the intake of provided meals, and fecal excretion of sodium and other minerals were determined. Urine was collected using a 24-hour urine collecting system to determine urinary excretion of sodium and other minerals. Results Fecal sodium excretion was significantly increased by intake of psyllium husk compared to placebo. Fecal excretion of other minerals (K, Ca, Mg, P, Cu, Zn, Mn, and Fe) had no significant differences. Conclusions The results suggest that ingestion of capsules containing psyllium husk increases fecal sodium excretion and suppresses intestinal sodium absorption. (UMIN000030586). © 2019 Life Science Publishing Co. Ltd. All rights reserved. 
Fat excretion; Psyllium husk; Sodium excretion; Sugar excretion