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8178262 
Journal Article 
Review 
Oxidative Stress in Parkinson's Disease: Potential Benefits of Antioxidant Supplementation 
Percário, S; da Silva Barbosa, A; Varela, ELP; Gomes, ARQ; Ferreira, MES; de Nazaré Araújo Moreira, T; Dolabela, MF 
2020 
1 
Oxidative Medicine and Cellular Longevity
ISSN: 1942-0900
EISSN: 1942-0994 
2020 
2360872 
English 
33101584 
WOS:000588450000003 
Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age and has become increasingly more common with advances in age. The number of individuals older than 60 years has been increasing in modern societies, as well as life expectancy in developing countries; therefore, PD may pose an impact on the economic, social, and health structures of these countries. Oxidative stress is highlighted as an important factor in the genesis of PD, involving several enzymes and signaling molecules in the underlying mechanisms of the disease. This review presents updated data on the involvement of oxidative stress in the disease, as well as the use of antioxidant supplements in its therapy.