Health & Environmental Research Online (HERO)


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8179210 
Journal Article 
Histomorphological study of DMBA-induced female rat breast cancer 
Jun, J; Yisheng, C; Fengxuan, L 
1998 
25 
6 
436-438 
Chinese 
Mammary gland precancerous lesion and cancer models were induced with 7,12-dimethylbenz[a] anthracence (DMBA) in Wistar rats. The histomorphological changes and its developing pattern were observed. It was demonstrated that after carcinogen DMBA was applied the mammary ductal epithelia of the rats underwent a series of pathological changes from proliferation, atypical hyperplasia culminating in carcinoma. Mammary gland carcinoma was found in 70% of the female Wistar rats within 24 weeks after administering DMBA. The features of histomorphology of the mammary gland carcinoma in female Wistar rat induced by DMBA were similar to those in human breast carcinoma. No mammary gland carcinoma was found in male rats. The study indicated that the histomorphological changes induced by DMBA in Wistar rats mammary gland resemble those in the development of some benign breast diseases in human being. 
Carcinogenesis; DMBA; Mammary gland; Wistar rat