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8182995 
Journal Article 
Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and ibuprofen: By initial solvent screening 
Lee, T; Kuo, CS; Chen, YH 
2006 
30 
10 
72-92 
English 
Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various solvent as a fingerprint for solute identification. The total "form space" for acetaminophen and racemic (±)-ibuprofen were calculated to be 222 and 257, respectively. Various crystal habits and sizes for ibuprofen and acetaminophen were observed. 
Active ingredients; Material characterization; Scale-up