Health & Environmental Research Online (HERO)


Print Feedback Export to File
8183488 
Journal Article 
Synthesis and preliminary antioxidant activity evaluation of new pyrrole based aryl hydrazones 
Tzankova, DG; Vladimirova, SP; Peikova, LP; Georgieva, MB 
2019 
Yes 
Bulgarian Chemical Communications
ISSN: 0861-9808 
Bulgarian Academy of Sciences 
51 
179-185 
English 
Six new hydrazones of ethyl 5-(4-bromophenyl)-1-(1-hydrazinyl-4-methyl-1-oxopentan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate were prepared in a micro synthesis conditions with 62 – 84 % yields. The applied synthetic methodology assured low harmful emissions and reagent economy. The performed IR, 1H, 13C NMR, MS spectral analysis and microanalysis were consistent with the assigned evaluated structures. The substances purity was confirmed by TLC characteristics and corresponding melting points. All new compounds were subjected for evaluation of their free radical scavenging activity; using classical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) tests. Compounds 5 and 5d were determined to express good DPPH activity, and three of the new structures (5, 5b and 5d) expressed good ABTS activity, when compared to butylated hydroxytoluene (BHT), used as a control. © 2019 Bulgarian Academy of Sciences, Union of Chemists in Bulgaria 
Pyrrole hydrazones; Radical scavenging activity; Synthesis