Makhatova, BG; Datkhayev, UM; Makhatov, ZB; Orazbekov, YK
Over the last 15 years, Staphylococcus aureus is one of the leading causative agents of postoperative and posttraumatic purulent wound complications in traumatology and orthopedics, such as osteomyelitis, abscess, cellulitis. Due to the frequent occurrence of multiple antibiotic resistance of Staphylococcus aureus is necessary to search for new high-performance antibacterial drugs. Verbascum songaricum Schrenk, a member of a genus Verbascum (Scrophulariaceae), is a biennial plant that traditionally used in folk medicine. Verbascum species reported to have expectorant, mucolytic and demulcent properties, and are used to treat respiratory disorders such as bronchitis, dry coughs, tuberculosis and asthma in traditional medicine of different nations. They also used to treat hemorrhoids, rheumatic pain, superficial fungal infections, wounds and diarrhea. The oil from the flowers of mullein is used to help soothe an earache and can be applied externally for eczema and other types of inflammatory skin conditions. Therefore, the aim of this study was to determine the antibacterial effects of the methanol, water, chloroform, ethyl acetate and hexane extracts of V. songaricum were investigated for their antimicrobial activity against microbial strains of Staphylococcus aureus using microdilution method. Water extract showed the highest activity against Staphylococcus aureus (growth=4.5837%), which is comparable with the activity of standard antibiotic (growth=2.4397). Also, Staphylococcus aureus was susceptible to the methanol extract of V. songaricum, the inhibition was 85.1770%. In conclusion, Verbascum songaricum water and methanol extracts demonstrating antibacterial activity against Staphylococcus aureus could result in the discovery of novel antibacterial agents; this may help to discover new antibiotics that could serve as selective agents against infectious diseases. © 2018, Yerevan State Medical University. All rights reserved.