Health & Environmental Research Online (HERO)


Print Feedback Export to File
8193936 
Journal Article 
Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd 
Rodrigues, DF; Maniscalco, DA; Silva, FA; Chiari, BG; Castelli, MV; Isaac, VL; Cicarelli, RM; López, SN 
2017 
1 
Planta Medica
ISSN: 0032-0943
EISSN: 1439-0221 
Georg Thieme Verlag 
83 
3-04 
239-244 
English 
27442262 
WOS:000397029700007 
The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Polygonum ferrugineum Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both Trypanosoma cruzi (IC50 = 9.5 µM, IC50 = 34.7 µM benznidazol, Y strain) epimastigotes and Trypanosoma brucei (IC50 = 4.8 µM, IC50 = 6.4 µM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on T. brucei strain 427 (IC50 = 6.2 µM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the trans-splicing inhibitory potential on T. brucei cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease. 
chalcone; flavokawin B; Polygonaceae; Polygonum ferrugineum; trans-splicing; Trypanosoma brucei; Trypanosoma cruzi