Health & Environmental Research Online (HERO)


Print Feedback Export to File
8209762 
Journal Article 
Synthesis and preliminary in-vitro cytotoxic activity of morpholino propoxy quinazoline derivatives 
Prajapati, B; Panchal, I 
2014 
0 
International Journal of ChemTech Research
ISSN: 0974-4290 
6 
1 
547-555 
English 
Present research work is about the synthesis and biological evaluation of morpholino propoxy quinazoline derivatives where in 7-methoxy-6-(3-morpholinopropoxy)3,4-dihydro quinazoline-4-one was converted in to 4-chloro-7-methoxy-6-(3-morphholinopropoxy)quinazoline by treating with Phosphorus oxychloride and N,N-diethyl aniline. 4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline condensed with various substituted aromatic amines and thiol using methanol gives various derivatives of 4-substituted morpholino propoxy quinazoline. Synthesized compounds were tested for their physicochemical properties and were further characterized by spectral analysis using FTIR, NMR and Mass spectroscopy. All synthesized compounds (compound I to VIII) were tested for their cytotoxicity by MTT assay. Among all the synthesized derivatives, compound-II was shown promising anticancer activity as compared to other synthesized derivatives. This was indicated by the IC50 value of (5.5 and 7.1) respectively for the synthesized derivatives (compound-I and II). And gefitinib shown experimental IC50 value 4.9μM. Study concluded efficient synthesis of the stated derivatives with the scheme and also prepared derivatives were with promising cytotoxic effect. 
4-dihydroquinazoline-4-one; 7-methoxy-6-(3-morpholinopropoxy)3; Anti-cancer; Benzo[d]thiazole; IC50; MTT assay