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8211238 
Journal Article 
Design, synthesis and biological evaluation of 2-[4-(aryl substituted)piperazin-1-yl]acetamido-5-chlorobenzophenone derivatives 
Verma, S; Kumar, S 
2017 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
Chemical Publishing Co. 
29 
2 
381-384 
English 
Substituted aryl piperazine and its derivatives have attracted great attention due to its diversity of pharmacological activities and its application in heterocyclic synthesis and medicines. It exerts its action on the CNS as it shows its strong affinity towards serotonin and dopamine receptors. The target compounds were synthesized by first reacting p-chloroaniline with chloroacetylchloride to obtain 2-chloro-N-(4-chlorophenyl)acetamide (1), the synthesized compound 1 was further treated with benzoyl chloride in the presence of aluminium chloride to get N-(2-benzoyl-4-chlorophenyl)-2-chloracetamide (2) and then treated with appropriate phenyl piperazine in DMF in the presence of potassium carbonate. The structures were confirmed on the basis of their TLC, IR, 1H NMR, 13C NMR and mass spectra. The physico-chemical parameters were also determined for blood brain barrier penetration. The log P values of the compounds tested showed that compounds have the potential to be CNS active. The compounds were evaluated for the skeletal muscle relaxant activity and it was found that piperazine derivatives possess significant differences between control group and treated group (P < 0.001). Among these derivatives, compound SA4 possesses the highest skeletal muscle relaxant activity. © 2017, Chemical Publishing Co. All rights reserved. 
Aryl piperazine; Blood brain barrier; Dopamine; Serotonin