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8212029 
Journal Article 
Gene-modified Exosomes Protect the Brain Against Prolonged Deep Hypothermic Circulatory Arrest 
Shi, J; Jiang, X; Gao, S; Zhu, Y; Liu, J; Gu, T; Shi, E; , 
2021 
Yes 
Annals of Thoracic Surgery
ISSN: 0003-4975
EISSN: 1552-6259 
ELSEVIER SCIENCE INC 
NEW YORK 
576-585 
English 
32652066 
WOS:000632527300056 
Neurologic deficit remains a major complication after cardiovascular surgeries with deep hypothermic circulatory arrest (DHCA). We hypothesized that exosomes derived from bone marrow mesenchymal stem cells (MSCs) may conduct cerebral protection against prolonged DHCA in rats, and overexpressing microRNA-214 (miR-214) may further enhance the neuroprotection.