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8212275 
Journal Article 
Evaluation of anticancer activity using hexanic extract of Vitex trifolia on two different cancer cell lines 
Vasanthi, VJ; Radhjeyalakshmi, R; Nasrin, F 
2014 
0 
International Journal of Pharmacognosy and Phytochemical Research
ISSN: 0975-4873 
International Journal of Pharmacognosy and Phytochemical Research 
6 
3 
449-453 
English 
The present study was designed to evaluate cytotoxicity of n-Hexane fractions of Vitex trifolia in two cancer cell lines viz., Hep G2 and HeLa. Different concentrations such as 20,40. 80, 160, 320 and 640 µg/ml of extract were tested for cytotoxicity using MTT Assay. Based on our previous research findings on qualitative and quantitive analysis of phytochemicals in Vitex trifolia, it was evident that phytochemicals in Vitex trifolia had strong antibacterial activity. Hence in the current study anticancer activity was tested using Vitex trifolia extracts. Concentration required for a 50% inhibition of viability (IC50) was determined graphically. MTT Assays showed that hexanic extract of Vitex trifolia were highly effective against both Hep G2 and HeLa cancer cell lines at a concentration of 80 µg/ml. This conclude that Vitex trifolia can be potent drug for cancer treatment and an alternative medicine. © 2014, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved. 
(HeLa); (Hep G2); Cell viability; Cytotoxicity; MTT Assay; Vero cell line; Vitex trifolia