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82127 
Journal Article 
Physiologically based models for bone-seeking elements. III. Human skeletal and bone growth 
O'Flaherty, EJ 
1991 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
111 
2 
332-341 
English 
1957316 
is related to other part(s) 049299 Physiologically based models for bone-seeking elements. II. Kinetics of lead disposition in rats
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is related to other part(s) 085107 Physiologically based models for bone-seeking elements. I. Rat skeletal and bone growth
A model of skeletal and bone growth for the human from birth to maturity has been developed. Dry and hydrated bone, bone marrow, ash, and calcium are included in the model. Growth of the skeleton and its fractions is expressed as a set of allometric equations relating fraction volume or weight to body weight. Blood flow rates to mature bone and bone marrow are scaled from experimentally determined values in smaller animals, but bone and marrow volumes and growth patterns cannot be scaled directly from measurements or models in small animals. The growth model compares well with measured bone weights, ash weights, and bone and skeletal densities in humans. Its form is adaptable to physiologically based description of the kinetics of bone-seeking elements. 
Adolescent; Adult; Aging/metabolism/physiology; Bone Development/physiology; Bone and Bones/blood supply/metabolism; Child; Child, Preschool; Elements; Female; Humans; Infant; Infant, Newborn; Male; Metals/pharmacokinetics; Minerals/pharmacokinetics; Models, Biological; 0 (Elements); 0 (Metals); 0 (Minerals)