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8214213 
Journal Article 
Synthesis and antifungal activity of 1-alkyl/H-2[4-(alkyl/ aryl-piperazin-1-yl)-methyl]-benzimidazole derivatives 
Amrutkar, SV; Bhagat, UD; Pargharmol, P; Kotgire, SS; Ranawat, MS 
2010 
1 
International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 
2 
2 
84-92 
English 
Benzimidazole and Piperizine are the most important group of systemic fungicides currently in use for controlling the fungal diseases. The major types of fungicidal piperizine derivatives are Ketoconazole, Itraconazole. Although these are effective against many groups of fungi, there are some major groups of fungi (e.g. Alternaria solani), which are quite insensitive to these compounds. In last decade many condensation products of benzimidazole and piperizines have been patented for variety of biological activities namely in the treatment of antibacterial, anti-inflammatory, antihypertensive, anthelmintic disorders. Therefore, we turned to synthesize various piperazinyl benzimidazole derivatives and decided to screen them for antifungal activity. Therefore in present work substituted benzimidazoles were condensed with various substituted piperazine to synthesize the library of benzimidazole derivatives. Substituted benzimidazoles were synthesized from corresponding o-phenylene diamines and then refluxed 8 hrs with monochloro acetic acid in concentrated hydrochloric acid. The substituted piperazines were condensed with substituted benzimidazole by refluxing in dioxane and Triethylamine as base. The antifungal activity of synthesized compounds was taken by using Disk diffusion method against Candida albicans using Ketoconazole as reference standard. The compound showed comparable antifungal activity to Ketoconazole. 
Antifungal activity; Benzimidazole; Piperazines