Gravimetric determination of the Cu (II) with schiff bases derived from sulfa drugs and 2-hydroxy, 1-napthaldehyde / benzoyl acetone | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8217244

Reference Type

Journal Article

Title

Gravimetric determination of the Cu (II) with schiff bases derived from sulfa drugs and 2-hydroxy, 1-napthaldehyde / benzoyl acetone

Author(s)

Patel, DP; Prajapati, SP; Patel, PS

Year

2012

Is Peer Reviewed?

Journal

Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585

Volume

Issue

Page Numbers

1-9

Language

English

Abstract

Compounds containing the sulphonamide group have long been used as drugs for diseases like cancer, tuberculosis, diabetes, malaria and leprosy etc. It has now been observed that some of these drugs show increased biological activity when administered in the form of metal complexes. A number of references are now available to show that the condensation products of sulpha drugs with aldehydes, ketones or their derivatives are biologically very active, besides having good complexing ability. The present works deals with the synthesis and preliminary characteristics of various ligands. Here all the ligands are Schiff bases. Schiff bases derived by the condensation 2-hydroxy, 1-napthaldehyde or benzoylacetone with some of the well-known sulpha drugs. After synthesis of such compound the physical properties like MP/BP, elemental analysis and spectral data of IR and NMR will be evaluated.

Keywords

Complexing; Ligands; Sulpha drugs; Sulphonamide