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8218082 
Journal Article 
Synthesis of Nitrogen Mustards of fluoro- benzothiazoles of pharmacological interest 
Barot Hitesh, K; Mallika, G; Sutariya Bhavin, B; Jitendra, S; Nargund, LVG 
2010 
0 
Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 
1 
1 
124-129 
English 
We have synthesized 2-amino-7-chloro-6-fluoro Benzothiazole(1) by using 4-fluoro-3-chloroaniline and potassium thiocyanate in presence of bromine in glacial acetic acid. which further treated with hydrazine hydrate and concentrated HCl to get 7-chloro-6-fluoro-2-hydrazino-1,3-benzothiazole (2). Then Schiff's base substituted benzaldehyde (7-chloro-6-fluoro-1,3-benzothiazol-2-yl)hydrazone (3a-e) is prepared by reaction of (2) with different type of aromatic aldehydes. This compound further treated with diethanolamine and triethylamine to get substituted benzaldehyde {7-[bis(2-hydroxyethyl) amino]-6-fluoro-1,3-benzothiazol-2-yl}hydrazone (4a-e). The structures of new compounds were established on the basis of spectral and elemental analysis. The title compound were screened for anti-bacterial (agar diffusion method) and anti-oxidant activity (ferric ion reduction method) and inhibition of denaturation of protein. Most of the compounds have shown promising activity. 
Anti-bacterial activity; Anti-oxidant activity; Fluoro benzothiazole; Nitrogen mustards