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8218659 
Journal Article 
Novel process for the synthesis of Zaleplon 
Naik, AM; Sawant, SD; Kavishwar, GA; Kavishwar, SG 
2010 
0 
International Journal of ChemTech Research
ISSN: 0974-4290 
2 
1 
1-3 
English 
The novel method for synthesis of Zaleplon is described in this novel approach, in which N-[3-[3-(dimethyl amino)-1-oxo-2-propenyl]phenyl] acetamide, dimethyl formamide, sodium hydroxide, tetrabutylammonium bromide, ethylbromide and p- Chloroaniline reacts in sequential manner and forms N-[3-[3-(p- chlorophenylamino)-1-oxo-2-propenyl] phenyl]-N-ethyl acetamide which on treatment with 3-amino -4-cyano pyrazole in hydrochloric acid gives N-[3-(3-Cyano pyrazolo [1, 5-a] Pyrimidin-7-yl) phenyl]-N-ethyl acetamide (Zaleplon). 
3-amino -4-cyano pyrazole; N-[3-(3-cyano pyrazolo [1, 5-a] pyrimidin-7-yl) phenyl]-n-ethyl acetamide; N-[3-[3-(dimethyl amino)-1-oxo-2-propenyl]phenyl] acetamide; N-[3-[3-(p-chlorophenylamino)-1-oxo-2-propenyl] phenyl]-n-ethyl acetamide; Zaleplon