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8218930 
Journal Article 
Hepatotherapeutic effects of Mikania scandens (L.) Willd. on paracetamol induced hepatotoxicity in rats 
Maity, T; Ahmad, A; Pahari, N 
2012 
1 
International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 
4 
SUPPL.3 
459-463 
English 
The present study is aimed to evaluating the hepatoprotective effect of Mikania scandens (L.) Willd.(MS) by paracetamol(PCM) induced liver damage in rats. Hepatoprotective action of MS extract and its fractions were evaluated using animal model of hepatotoxicity induced by Paracetamol. Liver marker enzymes were assayed in serum and antioxidant status was assessed in liver tissue. Hepatotoxicity in rats was achieved by intraperitoneal dose of 2 gm/kg of paracetamol for 14 days. The extract and the fractions of MS (500mg/kg) were administered orally to the animals with hepatotoxicity induced by paracetamol (2gm/kg). Silymarin (100mg/kg) was given as reference standard and studied by comparing parameters such as aspartate aminotrasferase(AST), alanine aminotrasferase(ALT), alkaline phosphatase (ALP),total bilirubin (TB), total protein (TP), triglycerides, cholesterol and the hepatic oxidative stress parameters like as levels of, malondialdehyde(MDA), reduced glutathione (GSH), catalase(CAT),super oxide dismutase (SOD) in rats. The results showed that plant extract and its fractions were effective in protecting the liver against the injury induced by paracetamol in rats. Histopathological studies also confirmed the hepatoprotective activity of these extracts when compared with Paracetamol treated groups. It can be concluded from the result that the plant Mikania scandens (L.)Willd possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats. 
Hepatoprotective; Hepatotoxicity; Histopathological study; Mikania scandens (L.) Willd; Paracetamol