A facile route for the synthesis of ethyl N-aryl-2,6-dioxo-piperid-3-ene-4-carboxylates and their biological activity | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8220302

Reference Type

Journal Article

Title

A facile route for the synthesis of ethyl N-aryl-2,6-dioxo-piperid-3-ene-4-carboxylates and their biological activity

Author(s)

Ajay Kumar, K; Lokanatha Rai, KM; Vasantha Kumar, G; Mylarappa, BN

Year

2012

Is Peer Reviewed?

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491

Volume

Issue

SUPPL. 4

Page Numbers

564-568

Language

English

Abstract

Cyclopropyl derivatives and piperidinediones have known to exhibit enormous amount of biological activities. In the present study the synthesis of biologically potent ethyl N-aryl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylates (2), N-aryl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acids (3) and ethyl 2,6-dioxo-N-aryl-piperid-3-ene-4-carboxylates (4) were described. The compounds (2, 4) were evaluated in vitro for their antibacterial, antifungal, antioxidant and reducing ability. The findings revealed that compounds (2) may be used as control measures against different bacterium and fungi, and (4) can be used as reference standard for antioxidant activities.

Keywords

Antibacterial; Antifungal; Antioxidant; Cyclopropane; Maleimides; Piperidinedione