US EPA

8221702 

Journal Article 

Antibacterial activity of extracts obtained from Mulinum spinosum and Mulinum echegarayii 

Satorres, SE; Chiaramello, A; Mattana, CM; Laciar, A; Rossomando, P; Tonn, C 

2012 

1 

SPL. 1 

128-132 

English 

Plants have always been a source of beneficial products to maintain health and increase the quality of human life. M. spinosum (Cav.) Pers. and Mulinum echegarayii Hieron are plants used in Argentine folk medicine. The antibacterial activity in vitro of organic extracts of this native species was evaluated against strains of methicillin-resistant Staphylococcus aureus ATCC 43300, Pseudomonas aeruginosa ATCC 27853, Listeria monocytogenes CLIP 74910, Escherichia coli and Bacillus cereus. Different organic extracts were prepared using solvents n-hexane, mixtures of n-hexane and ethyl acetate of increasing polarity and mixture ethyl acetate and methanol 2% on flash chromatography. Extracts of M. spinosum at 10% ethyl acetate/n-hexane and at 2% methanol/ethyl acetate and extracts of M.echegarayii n-hexane and at 10% ethyl acetate/n-hexane, showed activity against methicillin-resistant S. aureus. B.cereus and L. monocytogenes were sensitive to extract of M. spinosum at 2% methanol/ethyl acetate. The n-hexane extract of M. echegarayii only showed activity against S. aureus. All gram-negative bacteria were resistant to the extracts tested. This study contributes to the discovery of new plants with antibacterial properties and opens a way to isolation and identification of active principles with antibiotic activity. 

Antibacterial activity; Mulinum echegarayii; Mulinum spinosum