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8222772 
Journal Article 
Review 
Hollow micro and nanostructures for therapeutic and imaging applications 
Yasun, E; Gandhi, S; Choudhury, S; Mohammadinejad, R; Benyettou, F; Gozubenli, N; Arami, H; , 
2020 
Yes 
Journal of Drug Delivery Science and Technology
ISSN: 1773-2247 
ELSEVIER 
AMSTERDAM 
102094 
WOS:000601014600005 
Hollow particles have been extensively used in bioanalytical and biomedical applications for almost two decades due to their unique and tunable optoelectronic properties as well as their significantly high loading capacities. These intrinsic properties led them to be used in various bioimaging applications as contrast agents, controlled delivery (i.e. drugs, nucleic acids and other biomolecules) platforms and photon-triggered therapies (e.g. photothermal and photodynamic therapies). Since recent studies showed that imaging-guided targeted therapeutics have higher success rates, multimodal theranostic platforms (combination of one or more therapy and diagnosis modality) have been employed more often and hollow particles (i.e. nanoshells) have been one of the most efficient candidates to be used in multiple-purpose platforms, owing to their intrinsic properties that enable synergistic multimodal performance. In this review, recent advances in the applications of such hollow particles fabricated with various routes (either inorganic or organic based) were summarized to delineate strategies for tuning their properties for more efficient biomedical performance by overcoming common biological barriers. This review will pave the ways for expedited progress in design of next generation of hollow particles for clinical applications.