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8225014 
Journal Article 
Hydrotropy: A novel approach in estimation of poorly aqueous soluble drugs by TLC 
Sonali, J; Kamaldeep, Y; Bhumika, S; Sanjay, J; Kumar, MR 
2013 
1 
International Journal of Pharmacy and Pharmaceutical Sciences
ISSN: 2656-0097
EISSN: 0975-1491 
5 
2 
176-178 
English 
The thin layer chromatography (TLC) of drugs are usually performed with the help of solvents like butyl amine, toluene, ether, chloroform, light petroleum, ethyl acetate, ethanol, hexane, xylene and phenol, most of which are much expensive and toxic. In the present study, hydrotropic agents are employed as mobile phase for estimation of poorly aqueous soluble drugs by TLC technique. Erythromycin, Ciprofloxacin and Norfloxacin were selected as model drugs for estimation by TLC and Sodium Benzoate, urea, and Sodium Salicylate were taken as hydrotropic agents for mobile phase. TLC of selected model drugs were also performed by using proposed method given in Indian Pharmacopoeia (IP).The proposed TLC methods were new, simple, cost-effective, environment friendly and safe. In future, hydrotropic solutions shall prove a boon in TLC and high performance thin layer chromatography (HPTLC) analysis of a vast number of drugs thereby limiting the use of organic solvents to a great extent. 
Ciprofloxacin; Erythromycin; Hydrotropic solutions; Norfloxacin; Thin layer chromatography