US EPA

8225421 

Journal Article 

Formulation and evaluation of sustained release ciprofloxacin hydrocloride microspheres using synthetic polymers 

Wadher, KJ; Nagarkar, A; Sahare, D; Umekar, MJ 

2013 

5 

2 

773-780 

English 

Microspheres were prepared by solvent evaporation method Polymeric microspheres and microcapsules have received much attention as drug delivery systems in recent years as it improves the treatment by providing the localization of active substance at the site of action and bysustainong release of drugs. Ciprofloxacin hydrochloride is a first generation Fluroquinolone having a plasma half-life of three to five Thus, development of controlled release dosage forms would clearly be advantageous. The aim of this study was to formulate and evaluate microspheres as controlled release preparations of Ciprofloxacin HCL using Meth acrylic acid esters (Eudragit RS 100 L 100) as the retardant materials. The prepared microspheres were evaluated for drug content and entrapment efficiency and characterized by Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The in vitro release studies was performed in pH 7.4, phosphate buffer. The infrared spectra showed stable character of Indomethacin in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The results shows that, the yield percent, the actual drug content and the incorporation efficiencies of the prepared microspheres increased with increasing the drug: polymer ratio. The release rate of drug was found to be greater from the polymer Eudragit RS 100 as compared to Eudragit L 100, and the release rates were prolonged from both types of microspheres. 

Ciprofloxacin HCL; Eudragit L 100; Eudragit RS 100; Solvent evaporation technique