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8229476 
Journal Article 
Rapid determination of isonicotinic acid hydrazide in whole blood with 2,4,6-trinitrobenzenesulphonic acid 
Dymond, LC; Russell, DW 
1970 
Yes 
Clinica Chimica Acta
ISSN: 0009-8981
EISSN: 1873-3492 
27 
3 
513-520 
English 
1. (1) A spectrophotometric method for the quantitative determination of isonicotinic acid hydrazide (INH) in whole blood is described. 2. (2) The method involves reaction of INH with 2,4,6-trinitrobenzenesulphonic acid and extraction of the coloured product into methyl isobutyl ketone. The absorbance of the extract at 500 nm is proportional to INH concentration up to 30 μg/ml. 3. (3) Streptomycin and known metabolites of INH do not react, but p-amino-salicylic acid should be absent. © 1970.