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8245307 
Meetings & Symposia 
Fabrication of paper-based microfluidic devices by octadecyltrichlorosilane self-assembling and UV-patterning 
Ma, C; Bai, Z; He, Q; Chen, H 
2012 
Chemical and Biological Microsystems Society 
Okinawa 
16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 
1261-1263 
English 
Paper-based microfluidic devices are emerging as a new technology for simple, low-cost, portable, and disposable diagnostic and monitoring platform. This article presents a novel method for fabricating microfluidic devices on paper by means of octadecyltrichlorosilane self-assembling and UV/O3-patterning. The hydrophilic filter paper was uniformly coated with a hydrophobic layer of octadecyltrichlorosilane (OTS) by dipping the paper into an OTS-hexane solution. The coated OTS layer was then treated with UV/O3 through a patterned quartz mask, generating hydrophobic barriers that define hydrophilic fluid channels, reservoirs and reaction zones. Contact angle measurements, XPS and ATR-FT-IR spectra confirmed that OTS self-assembled layer (OTS-SAL) was chemically immobilized on the filter paper surface and that the monolayer was degraded after UV/O3 treatment. The widths of the prepared hydrophilic channels and hydrophobic barriers could be as small as 80 μm and 130 μm, respectively. Colorimetric assays of nitrite ions were demonstrated with the developed paper-based microfluidic devices. 
Paper-based microfluidics; Self-assembling; UV patterning